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MALDI-TOF spectra of tryptic digests of human butyrylcholinesterase inhibited with A) GF thiocholine Sp isomer, B) GF thiocholine Rp isomer, C) thiomethyl soman Rp isomer, D) tabun thiocholine Rp isomer. The inhibition reaction proceeded at 21°C for 17 h in pH 7.4 buffer with a 45-fold molar excess of nerve agent analog. Each MALDI spot contained 0.5 μl of 8.8 pmol/μl butyrylcholinesterase digest. The laser intensity was 3500 volts.
