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. Author manuscript; available in PMC: 2010 Oct 1.

Published in final edited form as: Chem Res Toxicol. 2009 Oct;22(10):1680–1688. doi: 10.1021/tx900090m

MS/MS spectra acquired on the MALDI-TOF-TOF mass spectrometer for peptide SVTLFGESAGAASVSLHLLSPGSHSLFTR of human butyrylcholinesterase. A) no label, B) methylphosphonate adduct produced by aging of GF, sarin, and soman adducts, C) aged tabun adduct, D) thiomethyl methylphosphonate adduct produced by reaction with thiomethyl sarin and soman model compounds, E) non-aged sarin adduct, F) non-aged tabun adduct, G) non-aged GF adduct, H) non-aged soman adduct. The delta symbol Δ designates masses that are consistent with loss of the phosphonate and a molecule of water. The boxed masses designate fragments that retain the phosphonate.

MS/MS spectra acquired on the MALDI-TOF-TOF mass spectrometer for peptide SVTLFGESAGAASVSLHLLSPGSHSLFTR of human butyrylcholinesterase. A) no label, B) methylphosphonate adduct produced by aging of GF, sarin, and soman adducts, C) aged tabun adduct, D) thiomethyl methylphosphonate adduct produced by reaction with thiomethyl sarin and soman model compounds, E) non-aged sarin adduct, F) non-aged tabun adduct, G) non-aged GF adduct, H) non-aged soman adduct. The delta symbol Δ designates masses that are consistent with loss of the phosphonate and a molecule of water. The boxed masses designate fragments that retain the phosphonate.