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. Author manuscript; available in PMC: 2010 Oct 25.
Published in final edited form as: Virology. 2009 Sep 5;393(2):338–345. doi: 10.1016/j.virol.2009.08.021

Figure 6.

Figure 6

Histopathology and immunohistochemistry of 1918 influenza virus and Sw31 influenza virus-infected ferret lung tissue. Photomicrographs of hematoxylin-and-eosin-stained tissue sections and immunohistochemically stained sections to detect influenza viral antigen from ferrets infected with 1918 influenza virus (A, C, E, G) and Sw31 influenza virus (B, D, F, H) at 4 dpi. Viral antigen (G, H) is stained red-brown on a hematoxylin-stained background. (A and B) Sections from ferret lungs show moderate-to-marked necrotizing bronchiolitis and alveolitis (original magnification 20x). (C and D) Sections show necrotizing alveolitis with abundant neutrophils (original magnification 40x). (E and F) Sections show alveolitis with intra-alveolar edema and hemorrhage (original magnification 20x). (G, H) Viral antigen (arrows) was observed in bronchiolar epithelial cells (original magnification 20x).