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. Author manuscript; available in PMC: 2010 Nov 2.
Published in final edited form as: DNA Repair (Amst). 2009 Aug 26;8(11):1258–1263. doi: 10.1016/j.dnarep.2009.07.009

Fig. 3.

Fig. 3

Effect of p53R2 overexpression on cell survival. (A) Characterization of p53R2 overexpressing CHO cell lines. Cell lysates of wild type (K1) and NHEJ-deficient (Xrs6) cells as well as myc-p53R2 overexpressing subclones of these cell lines (K+P, X+P) were probed for myc or actin in parallel Western blots. (B) Mean of three experiments comparing the frequency of survival for the NHEJ-deficient cell lines (Xrs6) after irradiation with 1 Gy relative to un-irradiated controls. Shown is mean +/− SEM. ***p53R2 overexpression made NHEJ-deficient cells significantly radioresistant; p<0.0001. (C) Mean of three experiments comparing the frequency of survival for the wild type CHO cell lines (K1) after irradiation with 1 Gy relative to un-irradiated controls. Shown is mean +/− SEM.