Table 1.
Sensitivity to ionizing radiation after pretreatment with hydroxyurea and aphidicolin at different stages of the cell cycle.
A (G1) | AA8 | irs1SF | V79 | V-C8 | K1 | Xrs6 | XR-1 | Xrs6 compl |
---|---|---|---|---|---|---|---|---|
HU (200μM) | 0.93 (0.06) | 0.94 (0.10) | 0.83 (0.04) | 1.16 (0.06) | 0.93 (0.04) | 0.75 (0.13) | 0.57 (0.11) | 0.88 (0.08) |
APH (1μg/ml) | 0.99 (0.06) | 0.85 (0.15) | 0.76 (0.04) | 0.85 (0.04) | 0.93 (0.04) | 0.83 (0.15) | 0.60 (0.09) | 0.91 (0.05) |
IR (1Gy) | 0.64 (0.05) | 0.51 (0.04) | 0.85 (0.04) | 0.66 (0.04) | 0.74 (0.05) | 0.027 (0.008) | 0.081 (0.010) | 0.71 (0.06) |
HU&IR | 0.54 (0.02) | 0.53 (0.06) | 0.66 (0.04) | 0.71 (0.02) | 0.63 (0.04) | 0.0051 (0.0015) | 0.0137 (0.0058) | 0.57 (0.03) |
APH&IR | 0.35 (0.04) | 0.37 (0.01) | 0.53 (0.03) | 0.70 (0.04) | 0.53 (0.04) | 0.0031 (0.0008) | 0.0116 (0.0084) | 0.61 (0.02) |
B (S) | AA8 | irs1SF | K1 | Xrs6 |
---|---|---|---|---|
HU (200μM) | 0.36 (0.04) | 0.38 (0.06) | 0.54 (0.05) | 0.28 (0.06) |
IR (1Gy) | 0.76 (0.04) | 0.46 (0.05) | 0.85 (0.02) | 0.0364 (0.0041) |
HU&IR | 0.12 (0.02) | 0.12 (0.02) | 0.35 (0.02) | 0.0019 (0.0007) |