Table 5.
Quality of life parameters at baseline and after 1 year rhGH replacement in patients with GHD after previous treatment for acromegaly
| Before | After | P-value | ||
|---|---|---|---|---|
| QoL NHP | Energy | 55.2 ± 38.2 | 41.8 ± 35.4 | 0.125 |
| Pain | 19.4 ± 21.8 | 14.1 ± 18.8 | 0.278 | |
| Emotional reaction | 12.0 ± 16.4 | 13.2 ± 20.0 | 0.603 | |
| Sleep | 13.6 ± 26.9 | 14.1 ± 24.4 | 0.913 | |
| Physical mobility | 20.1 ± 20.8 | 16.0 ± 23.7 | 0.258 | |
| Social isolation | 12.0 ± 17.1 | 10.6 ± 17.1 | 0.586 | |
| QoL MFI-20 | General fatigue | 15.4 ± 4.5 | 14.2 ± 4.7 | 0.154 |
| Physical fatigue | 12.9 ± 5.2 | 13.2 ± 5.2 | 0.747 | |
| Reduction in activity | 11.4 ± 4.9 | 11.8 ± 4.9 | 0.625 | |
| Reduction in motivation | 10.8 ± 4.4 | 10.1 ± 4.5 | 0.415 | |
| Mental fatigue | 9.3 ± 4.6 | 9.8 ± 4.3 | 0.650 | |
| QoL HADS | Anxiety | 4.6 ± 2.4 | 4.9 ± 2.3 | 0.453 |
| Depression | 6.0 ± 4.4 | 6.1 ± 4.3 | 0.933 | |
| Total score | 10.6 ± 5.0 | 11.0 ± 5.3 | 0.674 | |
| QoL-AGDHA | 7.6 ± 6.1 | 7.7 ± 5.9 | 0.880 |
HADS, NHP, MFI-20, QoL-AGDHA higher scores: more impairment