Figure 8.

(A) Expression of thyroid hormones T3 and T4 as a function of age (gray). Note the reduction of T3 and T4 levels at day 16 (black) due to pharmacologically-induced congenital hypothyroidism through inhibition of thyroid hormone expression with MMI (added to the drinking water). ND, not detectable. (B) Hypothyroidism did not affect titin isoform switching in gastrocnemius, TC, and soleus of 16-day-old mice. (Left) Typical gel result of gastrocnemius. CP, chicken pectoralis titin (as mobility standard). (Right) Quantification of relative titin size in gastrocnemius (gast), TC, and soleus.