FIG. 3.

Impact of SkE on the eythrocytic cycle of P. falciparum. A parasite culture synchronized on a 6-h period was subjected to 8-h pulses of SkE at the IC₅₀ (gray bars) and 1/10 the value (white bars). After the pulse, the culture was washed and returned to normal culture conditions until the beginning of the second erythrocytic cycle, and then parasitemia was determined. The scale bar at the top of the figure shows time (in hours). Major events along the eythrocytic cycle are shown. The dotted line shows protein synthesis, and the solid black line shows DNA synthesis. This figure was adapted from the Annals of Tropical Medicine and Parasitology (2) with the permission of the publisher.