TABLE 3.

Mean survival time of the treated mice and statistical significance

Treatment and routea	No. of mice	Mean survival time (days) [95% CI]b	Extended mean survival time (days)	Statistical significance (P value) compared to the following group:
				Control	CQ (i.p., 1 mg/kg/day)
Control	15	4.33 [3.76-4.91]
CQ	5	7.40 [6.70-8.10]		0.013
i.p.
1
5	5	12.80 [11.51-14.09]		<0.001	0.026
10	5	19.20 [16.82-21.58]c	43.87	<0.001	0.002
SkE
i.p.
0.5	5	16.40 [11.45-21.35]c	41.07	<0.001	0.005
1	5	18.60 [14.39-22.81]c	93.89	<0.001	0.003
5	5	11.40 [4.51-18.29]c	20.57	<0.001	0.047
p.o.
1	5	11.00 [6.46-15.54]c	13.61	<0.001	NSd
10	5	12.40 [8.42-16.38]c	15.01	<0.001	0.041
20	5	13.80 [9.32-18.28]c	16.41	<0.001	0.014

^aTreatment and routes were as follows: chloroquine (CQ) (1, 5, or 10 mg/kg/day for 4 days); simalikalactone E (SkE) (0.5, 1, 5, 10 or 20 mg/kg/day); p.o., oral route; i.p., intraperitoneal route.

^b95% CI, 95% confidence interval.

^cAs some mice were still alive at the end of the study, the largest observed analysis time was not available, and therefore, the mean is underestimated.

^dNS, not significant.