TABLE 5.
Post hoc Bayesian predicted pharmacokinetic parameters for PYR for PNG nonpregnant and pregnant women
| Parameter | Median [IQR]
|
Pa | |
|---|---|---|---|
| Nonpregnant (n = 30) | Pregnant (n = 30) | ||
| t1/2abs (h) | 0.41 [0.32-0.48] | 0.37 [0.29-0.47] | 0.234 |
| CL/F (liters/h) | 0.707 [0.571-0.875] | 1.040 [0.901-1.383] | <0.001 |
| VC/F (liters) | 108.0 [96.6-117.8] | 174.2 [148.8-232.1] | <0.001 |
| VP/F (liters) | 67.4 [53.9-82.3] | 184.3 [154.7-222.6] | <0.001 |
| Vss/F (liters) | 175.9 [150.9-200.1] | 381.6 [301.5-434.9] | <0.001 |
| t1/2α (h) | 51.9 [43.7-56.6] | 75.1 [60.9-84.5] | <0.001 |
| t1/2β (h) | 237.3 [211.3-261.9] | 450.1 [349.1-500.3] | <0.001 |
| AUC0-∞ (μg·h/liters) | 106,065 [85,693-131,350] | 72,115 [54,250-83,229] | <0.001 |
a
As determined by the rank-sum test.