TABLE 3.
MIC distributions for eight β-lactams and ciprofloxacin against 100 clinical isolates of BLPAR H. influenzae
Antimicrobial agent(s) | No. of isolates with MIC (μg/ml):
|
MIC (μg/ml)
|
% of isolates susceptiblea | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
≤0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | ≥64 | Range | 50% | 90% | ||
Ampicillin | 0 | 0 | 0 | 0 | 0 | 6 | 94 | —b | — | — | 4-≥8 | ≥8 | ≥8 | 0 |
Ampicillin-sulbactam | 0 | 0 | 9 | 41 | 25 | 17 | 8 | 0 | 0 | 0 | 0.5-8 | 0.25 | 0.5 | 75 |
Amoxicillin-clavulanate | 0 | 9 | 41 | 25 | 20 | 13 | 0 | 0 | 0 | 0 | 0.5-4 | 0.5 | 1 | 100 |
Piperacillin | 0 | 0 | 0 | 1 | 18 | 12 | 14 | 12 | 21 | 22 | 1->64 | 16 | >64 | |
Piperacillin-tazobactam | 99 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ≤0.03-0.25 | ≤0.03 | 0.06 | 100 |
Ceftriaxone | 97 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | — | — | ≤0.008-0.25 | ≤0.008 | 0.015 | 100 |
Imipenem | 13 | 19 | 18 | 18 | 2 | 2 | 1 | — | — | — | ≤0.12-≥8 | 1 | 1 | 99 |
Meropenem | 95 | 3 | 0 | 0 | 0 | 0 | 0 | — | — | — | ≤0.12 | ≤0.12 | ≤0.12 | 100 |
Ciprofloxacin | 98 | 2 | 0 | 0 | 0 | — | — | — | — | — | ≤0.03-0.25 | ≤0.03 | ≤0.03 | 100 |
CLSI MIC breakpoints (5).
—, untested concentration.