TABLE 5.
MIC distributions for β-lactams and ciprofloxacin against 100 clinical isolates of BLPACR H. influenzae
Antimicrobial agent(s) | No. of isolates with MIC (μg/ml):
|
MIC (μg/ml)
|
% of isolates susceptiblea | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
≤0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | ≥64 | Range | 50% | 90% | ||
Ampicillin | 0 | 0 | 0 | 0 | 0 | 0 | 100 | —b | — | — | ≥8 | ≥8 | ≥8 | 0 |
Ampicillin-sulbactam | 0 | 0 | 0 | 0 | 0 | 0 | 89 | 11 | 0 | 0 | 8-16 | 8 | 16 | 0 |
Amoxicillin-clavulanate | 0 | 0 | 0 | 0 | 0 | 0 | 96 | 4 | 0 | 0 | 8-16 | 8 | 8 | 0 |
Piperacillin | 0 | 0 | 0 | 0 | 0 | 1 | 17 | 15 | 25 | 42 | 4-≥64 | 32 | ≥64 | |
Piperacillin-tazobactam | 74 | 24 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ≤0.03-0.5 | 0.12 | 0.25 | 100 |
Ceftriaxone | 56 | 37 | 7 | 0 | 0 | 0 | 0 | 0 | — | — | ≤0.008-0.5 | 0.12 | 0.25 | 100 |
Imipenem | 1 | 3 | 7 | 37 | 45 | 5 | 2 | — | — | — | ≤0.12-≥8 | 2 | 2 | 98 |
Meropenem | 26 | 40 | 34 | 0 | 0 | 0 | 0 | — | — | — | ≤0.12-0.5 | 0.25 | 0.5 | 100 |
Ciprofloxacin | 91 | 6 | 2 | 0 | 1 | — | — | — | — | — | ≤0.03-≥2 | ≤0.03 | 0.12 | 99 |
CLSI MIC breakpoints (5).
—, untested concentration.