TABLE 6.
Phenotypes, MICs of ciprofloxacin, and QRDR mutations in H. influenzae isolates in the initial study
| Phenotype | MIC of ciprofloxacin (μg/ml) | No. of isolates with mutation(s) | Mutation(s) in QRDR:
|
|||
|---|---|---|---|---|---|---|
| gyrA | gyrB | parC | parE | |||
| BLNAS | 0.25 | 1 | Asp88Gly | Thr472Ile | Asp83Asn | |
| BLPAR | 0.25 | 1 | Ser84Leu | Ser84Arg/Asn138Ser | Asp364Gly | |
| 1 | Asp88Asn | Ser84Cys | Ala369Thr | |||
| 0.12 | 1 | Ala400Val | ||||
| 1 | Asp88Asn | Ser84Cys | Ala369Thr | |||
| 0.06 | 1 | Asp88Thr/Glu142Lys | ||||
| 2a | ||||||
| BLNAR | 0.06 | 1 | Ser84Leu | Ser133Ala/Asn138Ser | ||
| 1 | Ser84Leu | |||||
| 1 | Ser84Leu | Asn138Ser | Ser474Asn | |||
| 1 | Asp88Thr | Glu88Lys | ||||
| BLPACR | 16 | 1 | Ser84Leu/Asp88Gly | Glu88Lys | Val392Ile/Asp420Asn | |
| 0.5 | 2 | Ser84Leu | Ser84Ile/Asn138Ser | |||
| 0.25 | 6 | Asp88Asn | Ser84Cys | Asp364Thr | ||
| 0.12 | 9 | Asp88Asn | Ser84Cys | Ala369Thr | ||
| 1 | Asp88Asn | Ala369Thr | ||||
| 2a | ||||||
| 0.06 | 1 | Asp88Asn | Ser84Cys | Ala369Thr | ||
| 1 | Asp88Asn | Ala369Thr | ||||
| 1 | Asp88Thr | |||||
| 1a | ||||||
a
Number of isolates having no mutations in the indicated regions.