TABLE 1.
Recovery of C. albicans strain 03-2718 from vaginas of mice treated orally with ABC or FLC
| Vehicle or drug (dose [mg/kg] and frequency)a | Mean log10 CFU (range) on day postinoculationb:
|
|
|---|---|---|
| 1 | 6 | |
| Control [CMC] (BID) | 5.91 (5.09-6.88) | 5.34 (4.86-6.91) |
| Control [water] (BID) | 5.18 (4.41-7.10) | 5.16 (4.68-6.87) |
| ABC (5 OD) | 5.06 (3.94-6.36) | 4.99 (3.96-6.62) |
| ABC (5 BID) | 5.46 (4.79-6.11) | 4.82 (4.01-6.23) |
| ABC (10 OD) | 5.07 (4.10-6.07) | 4.33 (3.88-6.02) |
| ABC (10 BID) | 5.43 (4.88-6.90) | 3.83 (2.42-4.64)* |
| ABC (20 OD) | 5.13 (4.70-6.35) | 3.81 (2.22-4.27)* |
| ABC (20 BID) | 5.48 (4.98-7.95) | 3.34 (2.02-4.09)* |
| ABC (40 OD) | 5.62 (3.88-6.96) | 3.13 (1.96-4.00)* |
| ABC (40 BID) | 5.79 (4.65-6.44) | 2.24 (1.14-3.14)* |
| FLC (20 OD) | 5.51 (3.82-6.81) | 4.51 (2.83-5.97)* |
| FLC (20 BID) | 5.90 (4.80-6.99) | 3.74 (2.90-4.70)* |
a
CMC, carboxymethylcellulose; OD, once a day; BID, twice a day.
b
*, P < 0.05 vs. result for control.