TABLE 3.

Predicted probability of target attainment (AUC_0-24h/MIC ratio of >25) with Thai population

Dosing regimend	Breakpoint (%)			Proportion with adequate concentrations (%)
	1/19 mg/litera	2/38 mg/literb	3/57 mg/literc
TMP
160 mg q12h	18	<0.1	<0.1	44
160 mg q8h	80	2	<0.1	61
320 mg q12h	99	17	<0.1	72
320 mg q8h	100	81	18	85
Weight based	100	59	2	82
SMX
800 mg q12h	100	39	1.8	80
800 mg q8h	100	99	34	90
1,600 mg q12h	100	100	92	94
1,600 mg q8h	100	100	100	96
Weight based	100	100	100	95

^a1 (TMP)/19 (SMX) mg/liter represents the MIC₉₀ for Australian isolates.

^b2/38 mg/liter represents the susceptibility threshold.

^c3/57 mg/liter represents the MIC₉₀ for Thai isolates.

^dWeight-based dosing for patients was as follows: <40 kg (body weight), 160/800 mg q12h; 40 to 60 kg, 240/1,200 mg q12h; and >60 kg, 320/1,600 mg q12h.