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. 2009 Jul 20;53(10):4193–4199. doi: 10.1128/AAC.01301-08

TABLE 4.

Predicted probability of target attainment (AUC0-24h/MIC ratio of >25) with Australian patients

Dosing regimend Breakpoint (%)
1/19 mg/litera 2/38 mg/literb 3/57 mg/literc
TMP
    160 mg q12h 3 <0.1 <0.1
    160 mg q8h 36 0.2 0.1
    320 mg q12h 81 3 0.2
    320 mg q8h 100 36 3
    Weight based 100 31 0.6
SMX
    800 mg q12h 98 7 0.2
    800 mg q8h 100 66 7
    1,600 mg q12h 100 98 42
    1,600 mg q8h 100 100 98
    Weight based 100 100 98
a

1 (TMP)/19 (SMX) mg/liter represents the MIC90 for Australian isolates.

b

2/38 mg/liter represents the susceptibility threshold.

c

3/57 mg/liter represents the MIC90 for Thai isolates.

d

Weight-based dosing for patients was as follows: <40 kg (body weight), 160/800 mg q12h; 40 to 60 kg, 240/1,200 mg q12h; and >60 kg, 320/1,600 mg q12h.