TABLE 5.
Predicted probability of target attainment (concentration exceeding MIC for >60% of interdosing interval) in Thai patients
| Dosing regimend | Breakpoint (%)
|
Proportion with adequate concentrations (%) | ||
|---|---|---|---|---|
| 1/19 mg/litera | 2/38 mg/literb | 3/57 mg/literc | ||
| TMP | ||||
| 160 mg q12h | 13 | <0.1 | <0.1 | 57 |
| 160 mg q8h | 79 | 2 | <0.1 | 70 |
| 320 mg q12h | 98 | 13 | <0.1 | 85 |
| 320 mg q8h | 100 | 79 | 17 | 97 |
| Weight based | 100 | 93 | 25 | 91 |
| SMX | ||||
| 800 mg q12h | 100 | 31 | 1 | 88 |
| 800 mg q8h | 100 | 99 | 40 | 93 |
| 1,600 mg q12h | 100 | 100 | 86 | 96 |
| 1,600 mg q8h | 100 | 100 | 100 | 97 |
| Weight based | 100 | 100 | 100 | 97 |
a
1 (TMP)/19 (SMX) mg/liter represents the MIC90 for Australian isolates.
b
2/38 mg/liter represents the susceptibility threshold.
c
3/57 mg/liter represents the MIC90 for Thai isolates.
d
Weight-based dosing for patients was as follows: <40 kg (body weight), 160/800 mg q12h; 40 to 60 kg, 240/1,200 mg q12h; and >60 kg, 320/1,600 mg q12h.