TABLE 1.
Susceptibilities of the K. pneumoniae isolates and of the E. coli transconjugants obtained in the study
| Isolate(s) | MICa (μg/ml) of:
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AMP | AMC | PIP | TZP | CAZ | CTX | FEP | IPM | MEM | AMK | GEN | CIP | TET | TGC | CST | |
| Clinical isolates | >256 | >256 | >256 | >256 | >256 | 128 | >32 | 2-3 | 3-4 | 12-16 | 1-1.5 | >32 | 32-48 | 3 | 0.38-0.75 |
| KPC-2/TEM-1-producing transconjugant 2641/08 | >256 | 24 | 96 | 48 | 3 | 2 | 1.5 | 3 | 0.75 | 1.5 | 0.25 | 0.023 | 2 | 0.38 | 0.25 |
| SHV-12-producing transconjugants | >256 | 4-6 | 32-48 | 1-1.5 | 16 | 1.5-2 | 0.5 | 0.25 | 0.047 | 1-1.5 | 0.19-0.25 | 0.016 | 1.5-2 | 0.38-0.5 | 0.19-0.25 |
| E. coli A15 | 3 | 4 | 1.5 | 1 | 0.25 | 0.047 | 0.047 | 0.25 | 0.032 | 1 | 0.19 | 0.023 | 2 | 0.38 | 0.25 |
a
Abbreviations: AMK, amikacin; AMC, amoxicillin-clavulanic acid; AMP, ampicillin; CAZ, ceftazidime; CIP, ciprofloxacin; CST, colistin; CTX, cefotaxime; FEP, cefepime; GEN, gentamicin; IPM, imipenem; MEM, meropenem; PIP, piperacillin; TET, tetracycline; TGC, tigecycline; TZP, piperacillin-tazobactam. In the case of β-lactam antibiotics, the MICs shown are the values indicated by zones of confluent growth around Etest strips; the clinical isolates and the E. coli transformants with KPC-2 produced scattered colonies inside the growth inhibition zones (15).