TABLE 2.
Characteristics of nine recently infected patients and the recombinant clonal viruses constructed along with their amino acid polymorphisms within integrase
| Patient viral clone | Year of sample | Time since infection (days) | HIV-1 viral load (log10 copies/ml) | No. of CD4 cells/mm3 | Amino acids at specific codons in patient HIV-1 integrase as compared to those for R7/3a,c |
|---|---|---|---|---|---|
| F-15 | 1999 | NAb | 5.3 | NA | D10E, K42T, A124N, T125A, V126L, M154L, V201I, T206S, N232D, V281S |
| A-6 | 1996 | NA | 5.5 | 566 | D10E, V72I, A124T, M154I, R199K, V201I, N232D |
| R-6 | 2006 | 95 | 4.2 | 344 | D10E, E11D, S17N, A23V, L28I, P30A, V72I, L101I, S119T, T122I, A124T, V201I, N222D, N232D, S230G, D253E, N254G |
| R-31 | 1999 | 64 | 5.7 | 533 | D10E, E11D, V32I, V37I, V72I, L101I, T112I, A124N, T125A, K173R, A205S, Q216H, N222K, S230N, N232D |
| N-19 | 1998 | 21 | 5.9 | 605 | D10E, E11D, D25E, V31I, I113V, S119G, A124N, V151I, V201I, N232D |
| B-27 | 2000 | 75 | 6.3 | 218 | D10E, R20K, S39C, V72I, A124N, T125M, V201I, N232D |
| B-28 | D10E, R20K, S39C, V72I, A124N, T125V, V201I, N232D | ||||
| G-8 | 2000 | 69 | 4.9 | 367 | D10E, L101I, S119T, A124T, M154L, V201I, N232D, S283G |
| G-4 | 2002 | 28 | 6.6 | 213 | K7R, D10E, S39C, L74I, K156R, K215N, T218I, N232D, L234I |
| K-2 | 1998 | 35 | 4.9 | 361 | D10E, R20K, I113V, A124T, K188R, V201I, T206S, N232D, D278G |
a
R7/3 differs from HXB-2 at codons G123S and R127K.
b
NA, not available.
c
Mutations in bold have been associated with in vitro resistance pathways.