FIG. 4.

Inhibition of reactivation of chronic toxoplasmosis by artemisinin derivatives. (A) Murine model of reactivated toxoplasmosis. At day 0, IFN-γ^−/− mice were infected orally with 20 cysts of PRU-Luc-GFP, and 2 days later sulfadiazine (400 mg/kg) was administered for 3 weeks in the drinking water. Two days after discontinuation of the drug, compounds were administered for 8 days (s.c., 10 mg/kg), and survival was monitored. (B) Treatment with artemiside or artemisone resulted in increased survival following reactivation. Data shown are combined results from three individual experiments; n = 3 to 5 animals per group.