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In vivo antibacterial activities of vertilmicin and reference compound in mouse ascending urinary tract infections caused by E. coli 9612
| Antibiotic and dose (mg/kg) | Log CFU/g ( ± SD, n = 10) |
P value vs control |
|---|---|---|
| Vertilmicin | ||
| 20 | 2.36 ± 0.41 | <0.01 |
| 12 | 3.11 ± 0.34 | <0.01 |
| 7.2 | 3.07 ± 0.37 | <0.01 |
| 4.32 | 3.22 ± 0.48 | <0.01 |
| 2.59 | 3.32 ± 0.33 | <0.01 |
| Gentamicin | ||
| 40 | 2.78 ± 0.80 | <0.01 |
| 24 | 3.24 ± 0.48 | <0.01 |
| 14.4 | 3.34 ± 0.57 | <0.01 |
| 8.64 | 3.44 ± 0.63 | <0.01 |
| 5.18 | 3.71 ± 0.23 | >0.05 |
| Control | 4.45 ± 0.37 |
