TABLE 2.
Pharmacokinetic-pharmacodynamic parameters of the ciprofloxacin dosing regimen used in experimental UTI against the four E. coli strains used in the study
| E. coli strain (plasmid) | Pharmacokinetic- pharmacodynamic ratiosb
|
|
|---|---|---|
| Cmax/MICa | AUC0-24/MICc | |
| CFT703-RR | 147 | 827 |
| CFT703-RR Tc (pQnrA1) | 2.2 | 12.4 |
| CFT703-RR Tc (pQnrS1) | 4.4 | 24.8 |
| CT073-RR-gyrA | 4.4 | 24.8 |
a
The mean Cmax for ciprofloxacin was 1.1 ± 0.2 μg/ml.
b
The level of serum protein binding for ciprofloxacin in mice was near 0% (38). Therefore, the levels of total and unbound drug binding were considered similar.
c
The AUC0-24 value used was 6.2 ± 1.2 μg/h/ml.