. 2009 Jul 27;53(10):4292–4297. doi: 10.1128/AAC.01664-08

TABLE 2.

Pharmacokinetic-pharmacodynamic parameters of the ciprofloxacin dosing regimen used in experimental UTI against the four E. coli strains used in the study

E. coli strain (plasmid)	Pharmacokinetic- pharmacodynamic ratios^b
E. coli strain (plasmid)	C_max/MIC^a	AUC_0-24/MIC^c
CFT703-RR	147	827
CFT703-RR Tc (pQnrA1)	2.2	12.4
CFT703-RR Tc (pQnrS1)	4.4	24.8
CT073-RR-gyrA	4.4	24.8

The mean C_max for ciprofloxacin was 1.1 ± 0.2 μg/ml.

The level of serum protein binding for ciprofloxacin in mice was near 0% (38). Therefore, the levels of total and unbound drug binding were considered similar.

The AUC₀_-24 value used was 6.2 ± 1.2 μg/h/ml.