TABLE 3.
Effect of ciprofloxacin on viable organisms in kidneys of mice infected with the four E. coli strains used in the study
| E. coli strain (plasmid) | Results (log CFU/g of kidney ± SD [no. of mice]) for mice treated with:
|
||
|---|---|---|---|
| Start-of-treatment control | End-of-treatment control | Ciprofloxacin | |
| CFT703-RR | 5.0 ± 0.5 (15) | 5.0 ± 1.1 (15) | 3.6 ± 0.8 (15)a |
| CFT703-RR Tc (pQnrA1) | 3.4 ± 0.9 (15) | 3.0 ± 0.8 (15) | 2.7 ± 0.6 (16)b |
| CFT703-RR Tc (pQnrS1) | 4.6 ± 1.0 (15) | 4.5 ± 1.1 (15) | 4.2 ± 0.7 (16)b |
| CFT703-RR-gyrA | 3.9 ± 1.4 (15) | 4.0 ± 1.3 (15) | 4.1 ± 1.4 (16)b |
a
P was 0.001 compared with the end-of-treatment control group.
b
P was >0.2 compared with the end-of-treatment control group.