FIGURE 7.
Liver damage is Fas independent. A, Liver CD4+ T cells were isolated from 11-day-old littermate Tgfb1+/− mice (n = 3) and Tgfb1−/− mice (n = 3). mRNA was purified, converted to cDNA, and FasL and β-actin were measured by RT-PCR. “No RT” controls indicate mRNA samples to which reverse transcriptase was not added, showing that the PCR amplicons were not templated by contaminating genomic DNA. B, Plasma AST was measured from 11- to 12-day-old mice. Bars indicate mean + SD. Values of p are shown (n = 4–7 mice per group).