TABLE 4.
Rearrangements detected in peripheral blood of lymphoma patients undergoing treatment
| Patient | Draw | Site | Chromosome | Partner location (bp) | MLLmicrohomology partner |
|---|---|---|---|---|---|
| 1001 | 1st | 6805 | 1 | 78875267 | TGTTGTGAGCCTCTGTTTAACCCTTAA |
| 1st | 6872 | 18 | 17998961 | ATGGTTGATACCCAGCTCC | |
| 6 month | 6805 | 10 | 69640793 | CTGTTGTGAGCCACATAATAAGGTGTCAAA | |
| 1002 | 6 month | 6805 | 8 | 119562654 | TCTGTTGTGAGCCACTGCGCCCAGCCATT |
| 6 month | 6805 | 18 | 70836192 | TGTTGTGAGCCGTGGCACCTTAGGGC | |
| 6 month | 6804 | 4 | 133117976 | TGTTGTGAGCTTCCCTGTCCCACACAGGT | |
| 1003 | 3 month | 6846 | 9 | 97627491 | TCTGGAGGACCCCACATGGAGGAGTGG |
| 6 month | 6804 | 18 | 4240167 | ATTGCCAAGTCTGTTGTGAGCAGAAGAGAAA | |
| 6 month | 6625 | X | 41763674 | CTGTACTTACAGCAGGTGAGGTGGGG | |
| 1005 | 1st | 6804 | 12 | 11664603 | CTGTTGTGAGCCAAGACTGCGCCA |
| 1st | 6853 | 5 | 70816135 | GAGGACCTCATCTGAAGGAATGATAGA | |
| 1007 | 1 month | 6804 | 4 | 168956757 | TGTTGTGAGCTACAATGCTTTGGGGACCCAGA |
| 1009 | 1st | 6781 | 6 | 71299271 | AGTTTGGCTCGAACCCAGGAGG |
Draw refers to the time of blood collection after treatment was initiated. Most individuals exhibited more than one rearrangement per sample. Site is breakpoint location within MLL BCR (see Fig. 2) Translocation breakpoint highlights region of microhomology (bold). Partner location (breakpoint site) identified by BLAST using build 36.3 and refers to individual chromosome numbering in base pairs.