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. Author manuscript; available in PMC: 2010 Oct 15.
Published in final edited form as: Cancer Res. 2009 Oct 13;69(20):7986–7993. doi: 10.1158/0008-5472.CAN-09-2266

Figure 6. A GDH inhibitor sensitizes glioblastoma cells to glucose withdrawal and to inhibitors of glycolysis and Akt signaling.

Figure 6

A, The effect of EGCG on GDH activity was determined in glucose-deprived cells. B, Glioblastoma cells were cultured in the presence or absence of glucose, EGCG, CH3-Pyr and dm-αKG. The effects of these treatments, alone or in combination, were determined on cell viability at 8 and 16 hours. C, Glioblastoma cells were cultured in the presence or absence of EGCG, an Akt inhibitor or 2-DG, alone or in combination. After 24 hours, viability was determined by Trypan blue staining. In all experiments, the average and SD of three independent cultures are shown for each condition. *: p≤0.005.