Table 3.
Association of genetic variants in CASP7 gene with endometrial cancer risk by menopausal status, the Shanghai Endometrial Cancer Study, 1997–2003.
| Genotypes | Cases (%) | Controls (%) | P value | Age-adjusted OR (95%CI) | OR per allele | P for trend |
|---|---|---|---|---|---|---|
| Pre-menopausal women | ||||||
| rs11196418 | ||||||
| GG | 362(81.5) | 300(77.9) | 0.10 | 1.00 | ||
| AG | 80(18.0) | 78(20.3) | 0.86(0.61–1.22) | |||
| AA | 2(0.5) | 7(1.8) | 0.24(0.05–1.17) | 0.78(0.57–1.07) | 0.12 | |
| GA/AA | 82(18.5) | 85(22.1) | 0.20 | 0.81(0.58–1.14) | ||
| rs11593766 | ||||||
| TT | 387(87.4) | 308(80.0) | 0.02 | 1.00 | ||
| GT | 54(12.2) | 75(19.5) | 0.56(0.38–0.82) | |||
| GG | 2(0.5) | 2(0.5) | 0.94(0.13–6.74) | 0.60(0.42–0.86) | <0.01 | |
| GT/GG | 56(12.6) | 77(20.0) | <0.01 | 0.57(0.39–0.83) | ||
| rs3124740 | ||||||
| GG | 151(34.0) | 137(35.5) | 0.08 | 1.00 | ||
| CG | 206(46.4) | 196(50.8) | 0.96(0.71–1.30) | |||
| CC | 87(19.6) | 53(13.7) | 1.51(1.00–2.29) | 1.17(0.96–1.43) | 0.12 | |
| CG/CC | 293(66.0) | 249(64.5) | 0.65 | 1.08(0.81–1.44) | ||
| rs11196445 | ||||||
| GG | 295(67.2) | 286(74.5) | 0.02 | 1.00 | ||
| AG | 126(28.7) | 92(24.0) | 1.29(0.94–1.77) | |||
| AA | 18(4.1) | 6(1.6) | 2.95(1.15–7.56) | 1.41(1.08–1.85) | 0.01 | |
| AG/AA | 144(32.8) | 98(25.5) | 0.02 | 1.39(1.03–1.89) | ||
| rs10787498 | ||||||
| TT | 280(63.1) | 255(66.2) | 0.23 | 1.00 | ||
| GT | 143(32.2) | 120(31.2) | 1.09(0.81–1.47) | |||
| GG | 21(4.7) | 10(2.6) | 1.94(0.89–4.22) | 1.19(0.93–1.53) | 0.17 | |
| TG/GG | 164(36.9) | 130(33.8) | 0.34 | 1.15(0.87–1.54) | ||
| Post-menopausal women | ||||||
| rs11196418 | ||||||
| GG | 463(79.3) | 501(81.3) | 0.21 | 1.00 | ||
| GA | 117(20.0) | 106(17.2) | 1.20(0.90–1.61) | |||
| AA | 4(0.7) | 9(1.5) | 0.48(0.15–1.57) | 1.08(0.83–1.40) | 0.59 | |
| GA/AA | 121(20.7) | 115(18.7) | 0.37 | 1.14(0.86–1.52) | ||
| rs11593766 | ||||||
| TT | 496(85.2) | 516(83.8) | 0.72 | 1.00 | ||
| GT | 82(14.1) | 94(15.3) | 0.91(0.66–1.26) | |||
| GG | 4(0.7) | 6(1.0) | 0.69(0.19–2.46) | 0.89(0.67–1.20) | 0.45 | |
| GT/GG | 86(14.8) | 100(16.2) | 0.49 | 0.90(0.66–1.23) | ||
| rs3124740 | ||||||
| GG | 175(30.0) | 205(33.3) | 0.23 | 1.00 | ||
| CG | 280(48.0) | 298(48.4) | 1.10(0.85–1.43) | |||
| CC | 128(22.0) | 113(18.3) | 1.33(0.96–1.83) | 1.15(0.98–1.35) | 0.09 | |
| CG/CC | 408(70.0) | 411(66.7) | 0.23 | 1.16(0.91–1.49) | ||
| rs11196445 | ||||||
| GG | 407(70.3) | 432(70.4) | 0.86 | 1.00 | ||
| AG | 156(26.9) | 168(27.4) | 0.99(0.76–1.28) | |||
| AA | 16(2.8) | 14(2.3) | 1.21(0.58–2.52) | 1.02(0.82–1.27) | 0.85 | |
| AG/AA | 172(29.7) | 182(29.6) | 0.98 | 1.00(0.78–1.29) | ||
| rs10787498 | ||||||
| TT | 395(67.6) | 398(64.5) | 0.02 | 1.00 | ||
| TG | 161(27.6) | 204(33.1) | 0.80(0.62–1.02) | |||
| GG | 28(4.8) | 15(2.4) | 1.88(0.99–3.58) | 0.98(0.80–1.20) | 0.81 | |
| TG/GG | 189(32.4) | 219(35.5) | 0.25 | 0.87(0.69–1.11) |
P for interaction test for menopausal status with rs11196418, rs11593766, rs3124740, rs11196445 and rs10787498 were 0.26, 0.16, 0.54, 0.16 and 0.28, respectively.