Table 4.
Association of haplotypes in the CASP7 gene with endometrial cancer risk, the Shanghai Endometrial Cancer Study, 1997–2003.
| Haplotype | Frequency in cases (%) | Frequency in controls (%) | Age-adjusted OR (95%CI) |
||
|---|---|---|---|---|---|
| Dominant model | Additive model | Recessive model | |||
| CASP 7 | |||||
| Block 1a | |||||
| Hap1: AGTTAGGGGTC | 35.8 | 35.6 | 1.00 | 1.00 | 1.00 |
| Hap2: CGGTAGCGCCC | 17.0 | 16.3 | 1.04(0.86–1.26) | 1.06(0.88–1.27) | 1.12(0.76–1.65) |
| Hap3: CGTTAGCAGCC | 16.5 | 14.6 | 1.10(0.91–1.34) | 1.13(0.93–1.36) | 1.24(0.83–1.84) |
| Hap4: CATTGGGGGTT | 8.7 | 9.0 | 1.01(0.80–1.29) | 0.97(0.77–1.22) | 0.35(0.11–1.11) |
| Hap5: CGGTACCGGCC | 8.7 | 8.0 | 1.07(0.84–1.37) | 1.11(0.88–1.41) | 1.47(0.76–2.85) |
| Hap6: CGTGAGGGGCC | 7.1 | 9.0 | 0.78(0.61–1.00) | 0.80(0.63–1.02) | 0.90(0.39–2.07) |
| Block 2b | |||||
| Hap1: ATGGGC | 39.4 | 40.7 | 1.00 | 1.00 | 1.00 |
| Hap2: GTGGGC | 18.0 | 16.5 | 1.08(0.89–1.31) | 1.13(0.94–1.35) | 1.21(0.84–1.75) |
| Hap3: AGAGGC | 11.0 | 10.5 | 1.02(0.82–1.28) | 1.09(0.88–1.35) | 1.44(0.85–2.45) |
| Hap4: ATGAAC | 15.2 | 14.2 | 1.08(0.89–1.32) | 1.11(0.92–1.33) | 1.06(0.69–1.65) |
| Hap5: AGGGGG | 5.8 | 5.1 | 1.15(0.86–1.53) | 1.19(0.90–1.58) | 1.35(0.49–3.74) |
| Hap6: ATGAGC | 7.2 | 9.3 | 0.77(0.60–0.98) | 0.79(0.62–1.00) | 0.71(0.29–1.75) |
| Hap7: AGGGGC | 2.7 | 3.1 | 0.92(0.63–1.34) | 0.92(0.63–1.33) | -- |
a
In the order: rs12415607, rs11196418, rs7922608, rs11593766, rs11196438, rs11196444, rs3124740, rs11196445, rs3127075, rs17090904 and rs12359418.
b
In the order: rs6585241, rs10787498, rs12247479, rs1127687, rs17090919 and rs10885497.