Table 5.
Association of haplotypes in the CASP7 gene with endometrial cancer risk stratified by menopausal status, the Shanghai Endometrial Cancer Study 1997–2003.
| Haplotype | Age-adjusted OR (95%CI) |
||
|---|---|---|---|
| Dominant | Additive | Recessive | |
| Pre-menopausal women | |||
| Block 1a | |||
| Hap1:AGTTAGGGGTC | 1.00 | 1.00 | 1.00 |
| Hap2:CGGTAGCGCCC | 0.81(0.59–1.11) | 0.89(0.66–1.21) | 1.49(0.81–2.76) |
| Hap3:CGTTAGCAGCC | 1.20(0.88–1.64) | 1.25(0.92–1.68) | 1.52(0.85–2.70) |
| Hap4:CATTGGGGGTT | 0.82(0.57–1.19) | 0.78(0.55–1.12) | 0.25(0.03–1.79) |
| Hap5:CGGTACCGGCC | 1.12(0.77–1.64) | 1.11(0.76–1.61) | 0.91(0.28–2.97) |
| Hap6:CGTGAGGGGCC | 0.60(0.40–0.88) | 0.61(0.42–0.89) | 0.65(0.15–2.71) |
| Block 2b | |||
| Hap1:ATGGGC | 1.00 | 1.00 | 1.00 |
| Hap2:GTGGGC | 0.78(0.57–1.07) | 0.87(0.65–1.16) | 1.29(0.70–2.36) |
| Hap3:AGAGGC | 1.12(0.80–1.56) | 1.16(0.84–1.61) | 1.29(0.58–2.88) |
| Hap4:ATGAAC | 0.96(0.70–1.30) | 1.04(0.77–1.39) | 1.41(0.77–2.59) |
| Hap5:AGGGGG | 1.19(0.76–1.86) | 1.25(0.80–1.94) | 1.50(0.35–6.39) |
| Hap6:ATGAGC | 0.59(0.40–0.88) | 0.62(0.42–0.91) | 0.67(0.16–2.79) |
| Hap7: AGGGGC | 0.76(0.41–1.40) | 0.76(0.41–1.40) | -- |
| Post-menopausal women | |||
| Block 1a | |||
| Hap1:AGTTAGGGGTC | 1.00 | 1.00 | 1.00 |
| Hap2:CGGTAGCGCCC | 1.27(0.99–1.63) | 1.23(0.97–1.55) | 0.95(0.57–1.58) |
| Hap3:CGTTAGCAGCC | 1.07(0.82–1.38) | 1.08(0.85–1.39) | 1.05(0.60–1.83) |
| Hap4:CATTGGGGGTT | 1.20(0.88–1.64) | 1.15(0.85–1.56) | 0.43(0.10–1.77) |
| Hap5:CGGTACCGGCC | 1.06(0.77–1.47) | 1.15(0.84–1.57) | 1.97(0.88–4.38) |
| Hap6:CGTGAGGGGCC | 0.97(0.70–1.35) | 1.00(0.73–1.38) | 1.11(0.40–3.08) |
| Block 2b | |||
| Hap1:ATGGGC | 1.00 | 1.00 | 1.00 |
| Hap2:GTGGGC | 1.35(1.06–1.73) | 1.34(1.07–1.68) | 1.16(0.73–1.84) |
| Hap3:AGAGGC | 0.95(0.71–1.27) | 1.03(0.78–1.36) | 1.52(0.75–3.07) |
| Hap4:ATGAAC | 1.19(0.92–1.53) | 1.16(0.91–1.49) | 0.84(0.44–1.57) |
| Hap5:AGGGGG | 1.13(0.77–1.64) | 1.16(0.80–1.68) | 1.23(0.29–5.13) |
| Hap6:ATGAGC | 0.93(0.67–1.28) | 0.94(0.69–1.28) | 0.74(0.23–2.38) |
| Hap7: AGGGGC | 1.06(0.66–1.71) | 1.05(0.65–1.69) | -- |
a
In the order: rs12415607, rs11196418, rs7922608, rs11593766, rs11196438, rs11196444, rs3124740, rs11196445, rs3127075, rs17090904 and rs12359418.
b
In the order: rs6585241, rs10787498, rs12247479, rs1127687, rs17090919 and rs10885497.
P for interaction tests for menopausal status with Hap6 in block 1 was 0.61, and with Hap2 and Hap6 in block 2 were 0.0006 and 0.33, respectively, under the additive model.