Table 1.
Transcription factors controlling hepatic glycolysis, fatty acid synthesis and oxidation
| Protein | SREBP-1 | ChREBP/MLX | PPARα |
|---|---|---|---|
| Glycolysis and gluconeogenesis | |||
| Glucose transporter-2 (Glut2) | (+) | ||
| L-Pyruvate kinase (L-PK) | (+) | (−) | |
| Phosphoenolpyruvate carboxykinase (PepCk) | (−) | (+) | |
| Fatty acyl synthetases and thioesterases | |||
| Fatty acyl synthetase 1 (ACS1) | (+) | ||
| Cytosolic fatty acyl thioesterase (CTEI) | (+) | ||
| Mitochondrial fatty acyl thioesterase (MTEI) | (+) | ||
| Peroxisomal fatty acyl thioesterase (PTEI) | (+) | ||
| Fatty acid synthesis, desaturation and elongation | |||
| ATP citrate lyase (ACL) | (+) | (+) | |
| Acetyl CoA carboxylase (ACC) | (+) | (+) | |
| Fatty acid synthase (FAS) | (+) | (+) | |
| Δ5-desaturase (Δ5D) | (+) | (+) | |
| Δ6-desaturase (Δ6D) | (+) | (+) | |
| Stearoyl CoA desaturase (Δ9D) | (+) | (+) | (+) |
| Fatty acid elongase-5 (Elovl5) | (+) | ||
| Fatty acid elongase-6 (Elovl6) | (+) | (+) | (+) |
| Fatty acid oxidation | |||
| Mitochondrial HMG CoA synthase (mtHMGCoASyn) | (+) | ||
| Peroxisomal acyl CoA oxidase (AOX) | (+) | ||
| Microsomal cytochrome P450-4A (Cyp4A) | (+) | ||
(+), Transcription factor induces enzyme expression; (−), transcription factor represses enzyme expression.