Table 3.

Noncompartmental pharmacokinetic parameters of cyclosporine following an intravenous administration of 5 mg/kg in healthy and diabetic beagle dogs.

Parameter	Estimate (Mean ± SEM)
	Healthy dog	Diabetic dog	P value
Co (μg L−1)	3680.50 ± 661.58	3721.28 ± 638.62	.8801
MRT (hr)	25.73 ± 3.04	10.6313 ± 2.35	.0098
AUC0−t (μg*hr L−1)	15892.66 ± 1225.49	10144.39 ± 1113.72	.0119
AUC0−∞ (μg*hr L−1)	25181.39 ± 1513.63	12110.47 ± 1881.94	.0019
CL (L hr−1 kg−1)	0.201 ± 0.010	0.457 ± 0.076	.0019
Vss (L Kg−1)	5.12 ± 0.57	4.19 ± 0.45	.2468
λz (hr−1)	0.032 ± 0.003	0.106 ± 0.037	.0125
T1/2λ (hr)	22.56 ± 2.3042	9.3194 ± 2.2896	.0125