Table 2.
Sham (n=7) 8 weeks | SIRI (n=8) 8 weeks | SIRI+V (n=7) 8 weeks | SIRI+Rap (n=7) 8 weeks | |
---|---|---|---|---|
Body weight (g) | 24.7±0.85 | 25.1±0.6 | 26.1±0.5 | 25.7±0.6 |
24 h calorie intake (kcal) | 14.1±0.75 | 20.1±1.5* | 14.1±1.0 | 20.4±1.3* |
24 h water intake (ml) | 1.130±186 | 3.599±757* | 3.630±510* | 6.333±646* |
24 h urine volume (ml) | 1.110±60 | 3.420±180* | 3.640±840* | 6.422±930* |
Lean body mass (g) | 20.3±0.8 | 19.2±1.2 | 20.3±1.4 | 19.9±1.3 |
Fat body mass (g) | 4.1±0.3 | 3.9±0.2 | 4.4±0.2 | 4.3±0.2 |
Extracellular fluid volume (ml) | 4.13±1.24 | 4.10±0.89 | 4.21±0.99 | 4.02±1.16 |
Lung weight/BW (mg/g) | 6.45±0.9 | 6.21±0.9 | 6.27±0.0.5 | 6.59±0.6 |
Liver weight/BW (mg/g) | 26.12±2.4 | 26.82±2.0 | 27.06±4.4 | 26.55±1.9 |
Spleen weight/BW (mg/g) | 2.52±0.3 | 2.71±0.4 | 2.93±0.3 | 2.62±0.4 |
Metabolic analysis of 20-week-old mice after sham surgery (Sham), surgically induced renal injury (SIRI), SIRI with daily injections of vehicle (SIRI+V), or SIRI with daily injections of rapamcyin (SIRI+Rap).
P<0.05 vs sham-operated mice at the same time point.