. Author manuscript; available in PMC: 2009 Oct 20.

Published in final edited form as: Kidney Int. 2009 Jan 21;75(8):800–808. doi: 10.1038/ki.2008.690

Table 3.

Echocardiographic analysis of mice after renal injury

	Sham (n=12) 4 weeks	SIRI (n=15) 4 weeks	Sham (n=7) 8 weeks	SIRI (n=8) 8 weeks	SIRI+V (n=7) 8 weeks	SIRI+Rap (n=7) 8 weeks
HR (bpm)	613±58	618±31	629±12	637±9	599±12	616±15
PWd (mm)	0.76±0.06	0.89±0.09^*	0.76±0.02	0.92±0.02^*	0.85±0.05^*	0.78±0.02^†
IVSd (mm)	0.83±0.02	0.94±0.03^*	0.84±0.02	1.03±0.03^*	0.90±0.03	0.89±0.04^†
LVEDD (mm)	3.3±0.08	3.2±0.06	3.4±0.09	3.2±0.06	3.2±0.07	3.0±0.04
LVM (mg)	84±2.8	99±4.2^*	88±3.7	106±2.2^*	94±4.9	76.1±3.9^†
LVMI (mg/g)	3.22±0.08	3.78±.14^*	3.20±0.15	3.96±0.11^*	3.63±0.17^*	2.94±0.18^†
FS (%)	63±1.0	62±1.2	64±1.0	65±0.9	65±1.4	65±1.9

HR, heart rate; PWd, left ventricular posterior wall thickness in diastole; IVSd, interventricular septal wall thickness in diastole; LVEDD, left ventricular end-diastolic diameter; LVM, calculated LV mass (mg); LVMI, left ventricular mass index (LVM/body weight) mg/g; FS, fractional shortening of the left ventricle in systole.

Transthoracic echcardiographic analysis of mice 4 or 8 weeks after sham surgery (Sham), subtotal nephrectomy (SIRI), SIRI with daily injections of vehicle (SIRI+V), or SIRI with daily injections of rapamcyin (SIRI+Rap). Daily injections of vehicle or rapamycin were initiated 4 weeks after SIRI and were given for 4 weeks.

P<0.05 for all comparisons vs sham-operated mice at the same time point except LVMI, where P<0.021;

^†

P<0.05 for all comparisons vs SIRI mice injected with vehicle at the same time point except LVMI, where P<0.021.