Figure 1.

Human p63 gene. (A) Schematic representation of human p63 gene structure: alternative promoters (P1 and P2), previously identified alternative splicing events (α, β and γ) and novel events (δ and ϵ) are indicated. (B) ΔNp63 protein isoforms are reported with their molecular size. TA1*: TA of ΔN isoforms; DBD: DNA-binding domain; OD: oligomerization domain; TA2: C-terminal TA; SAM: sterile alpha motif; TI: inhibitory domain. (C) Amino acid alignment among the C-terminal regions of δ and ε p63 proteins and the known α, β and γ.