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Anti-p65 R1 RNA aptamer improved secondary structure model. (A) Plot of optimal and sub-optimal predicted R1 secondary structures and concordance with prior V1 nuclease susceptibility data (25). Arrow indicates candidate fold. (B) Depiction of prior V1 nuclease susceptibility data (bold) in this context. (C) Tolerated R1 mutations (Table 1) are indicated by arrows. Mutations that enhanced R1 function in the Y3H are indicated in bold.
