Figure 4.
Thromboembolism model. (A) Thromboembolic mortality was observed following the injection of collagen plus epinephrine (Epi) or collagen plus ADP as described in Methods. The P values (NS, statistically nonsignificant) shown in the figure were calculated by the χ2 test. (B) Lung sections from mice challenged with collagen plus epinephrine are shown. The figure represents data obtained from three animals of each genotype or time point. Large thrombi in large vessels were found only in the wild-type mice (indicated by large arrows). Smaller thrombi that are widespread in the (+/+) samples, but are much less frequent in (−/−) samples, are also indicated (small arrows). The (−/−) mice killed 1 h after challenge are clear of obvious clots.