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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Gastroenterology. 2009 Jun 26;137(4):1403–1414. doi: 10.1053/j.gastro.2009.06.049

Figure 7. Expression of FoxO4 is downregulated during inflammation.

Figure 7

(A) Representative micrographs of colonic mucosal biopsies from patients with active UC (middle panel), normal tissues (Norm, left panel), and inactive UC (iUC, right panel) stained with anti-FoxO4 antibody. (B) Immunohistochemistry of FoxO4 in epithelial cells was scored from colonic tissue samples of individual patients with active UC and normal controls (n=10, *, p<0.01). (C) WT mice were given a single dose of ethanol (vehicle) and TNBS intrarectally. Colonic mucosal mRNA of Foxo4 and Foxo3 following the treatment was measured by qRT-PCR (n=4, *, p<0.01).