Fig. 1.
Overall structure of C-CggR.
A. Topology diagram of C-CggR. The central NAD-binding fold subdomain is shown in yellow, and the three peripheral subdomains P1, P2 and P3 are coloured red, blue and green respectively. β strands are numbered sequentially, and α helices are referred to by letters for each domain separately. Residue numbers are indicated, and the region undergoing structural rearrangements upon ligand binding (flap) is outlined in orange.
B. Ribbon representation of the overall structure of C-CggR. The location of the effector-binding site is indicated by an asterisk. The colour coding is identical to the one used in A.