Figure 1.

Mutation induction at minisatellite loci in mice. (a and b) Frequencies of paternal and maternal mutation in offspring conceived 3, 6, and 10 weeks after paternal irradiation by 1 Gy of x-rays (a, aggregated data; b, frequency of mutations in each family). (c and d) Dose–response curves for minisatellite mutations induced in premeiotic cells. (c) Aggregated data. (d) Frequency of paternal mutation in each family (r = 0.6131; P = 2.0 × 10⁻⁵ and r = 0.0888; P = 1.0000 for the arcsine-transformed values of paternal and maternal mutation rates, respectively. Values of Bonferroni probabilities for the coefficients of correlation are given). Dashed lines indicate 95% confidence intervals for the linear regression. The 95% confidence intervals for mutation rate, estimated from the Poisson distribution and probabilities of difference between paternal and maternal rates (Fisher’s exact test, two-tailed) are shown for aggregated data.