Table 4.

Estimates of the gonadal doubling dose for acute radiation of spermatogonia in mice

System	Spontaneous mutation rate	Total tested*	Exposure, Gy	Doubling dose, Gy†	Ref.
Russell 7-locus	7.95 × 10−6	1,051,869	3, 6, 6.7	0.34 (0.22, 0.50)	22, 23
Dominant visibles	8.11 × 10−6	225,017	6, 12	0.17 (0.00, 0.59)	23
Dominant cataract, 30 loci	7.38 × 10−7	107,369	1.5-6	0.56 (−0.14, 3.75)	24
Enzyme activity, 12 loci	2.85 × 10−6	36,422	6	0.44 (−0.09, 2.68)	25
Skeletal malformations	2.88 × 10−4	2,493	6	0.27 (−0.07, 1.67)	23
Semisterility	1.04 × 10−3	2,124	12	0.31 (0.03, 0.95)	23
Minisatellites, 2 loci	5.56 × 10−2	252	0.5, 1	0.33 (0.06, 0.75)	This paper
Mean for 7 systems	—	—	—	0.35 (0.20 0.95)

^*Including offspring from the control and irradiated parents. 

^†The lower and upper 95% confidence limits computed from the Poisson distribution are given in parentheses.