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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Neurochem Int. 2009 Jul 19;55(8):732–740. doi: 10.1016/j.neuint.2009.07.005

Fig 3. The ratio of GAT1-mediated charge flux to GABA flux is not altered by SKF-89976A.

Fig 3

GABA uptake was performed under voltage clamp in the presence of 5 μM SKF-89976A (A-C) or 25 μM SKF-89976A (D-F) at −50 mV (B and E) and −90 mV (C and F). GABA was 500 μM and [3H]-GABA was 28 nM. In the presence of 5 μM SKF-89976A, the ratio of charge flux to GABA flux (e/GABA) was 1.9 ± 0.1 at −50 mV (n = 9) and 1.9 ± 0.1 at −90 mV (n = 10). In the presence of 25 μM SKF-89976A, the ratio of charge flux to GABA flux was 2.0 ± 0.1 at −50 mV (n = 8) and 2.1 ± 0.1 at −90 mV (n = 7). In each panel, the smooth line is a linear regression through the data points.