Table 1.

HLA Class I Allele Frequencies for NPC Affected and Unaffected Groups from the NPC Family Study in Taiwan

	Case (n=602)	Sibling Controls (n=962)		Spouse Controls (n=424)
	%	%	pvalue*	%	pvalue*
HLA-A alleles
101	0.2	0.4		1.2	0.04
201	8.8	8.1		9.9
203	7.6	8.0		5.7
206	2.0	2.2		2.4
207	16.1	15.3		11.6	0.04
224	0.0	0.0		0.2
1101	17.4	21.6	0.04	29.3	<0.0001
1102	3.3	4.0		3.8
2402	23.1	19.0		17.9
2403	0.2	0.3		0.2
2407	0.0	0.5		0.5
2410	0.0	0.5		0.2
2601	3.7	5.4		3.5
2901	0.3	0.3		0.0
3001	0.7	0.6		0.9
3101	1.0	0.5		1.4
3201	0.2	0.0		0.0
3303	14.6	12.6		10.9
HLA-B alleles	Case (n=590)	Sibling Controls (n=946)		Spouse Controls (n=416)
1301	4.4	5.4		6.7
1302	1.7	1.2		1.0
1301/1302	6.1	6.6		7.7
1501	4.9	4.2		3.6
1502	3.4	3.7		6.0
1505	0.0	0.1		0.2
1511	0.3	0.7		1.0
1512	0.2	0.3		0.0
1518	1.0	0.4		0.2
1525	0.2	0.2		1.0
1527	0.3	0.1		0.2
1802	0.2	1.0		0.2
2704	0.9	2.4	0.02	3.1	0.01
2706	0.2	0.2		0.0
3501	2.0	2.0		3.1
3505	0.2	0.2		0.2
3701	0.2	0.3		0.0
3802	6.1	5.9		2.6	0.01
3901	1.2	2.2		2.6
4001	20.5	21.7		20.7
4002	2.7	1.7		1.7
4006	2.4	1.4		0.7
4403	0.3	0.0		0.5
4601	18.3	16.5		16.8
4801	1.5	1.2		1.4
5101	4.8	4.9		3.9
5102	0.2	0.3		1.0
5201	0.5	0.0	0.03	0.5
5401	2.2	2.8		2.6
5502	1.0	2.5	0.04	2.9	0.03
5504	0.0	0.7	0.04	0.5
5603	0.5	0.1		0.7
5701	0.0	0.1		0.7	0.04
5801	14.9	12.8		10.1	0.02
6701	0.9	0.2		0.0
8101	0.0	0.0		0.2

Bolded rows indicate an alleleic freq ≥ 5%

Highlighted rows indicate alleles with allelic frequency ≥ 5% and p-value <0.05.

^*Only p-values<0.05 from Pearson's X² or Fisher's exact tests (n/cell <5) are shown. All statistical tests are two-sided.