Table 5.

CATHGEN: Association of SNPs with CAD by smoking among the Young Affected.

		Basic Model*		Full Model†
GENE	SNP name	OR‡ (95% CI)	p-value	OR‡ (95% CI)	p-value
SMOKERS (n=353 [238 YA, 115 Controls])
CDGAP	rs10934490	1.23 (0.87, 1.73)	0.24	1.27 (0.87, 1.85)	0.22
MYLK	rs16834817	2.09 (1.16, 3.77)	0.014	2.45 (1.30, 4.60)	0.006
KALRN	rs6810298	1.74 (1.18, 2.54)	0.005	1.71 (1.13, 2.60)	0.011
	rs9289231	2.69 (1.35, 5.37)	0.005	3.22 (1.52, 6.82)	0.002
	rs12637456	2.38 (1.59, 3.55)	<0.001	2.28 (1.47, 3.52)	<0.001
	rs1444768	1.93 (1.34, 2.79)	<0.001	1.94 (1.30, 2.89)	0.001
	rs1444754	1.57 (1.12, 2.19)	0.009	1.45 (1.02, 2.08)	0.041
	rs4234218	1.49 (1.06, 2.09)	0.022	1.46 (1.00, 2.13)	0.0498
GATA2	rs2335052	0.99 (0.61, 1.60)	0.95	0.87 (0.51, 1.49)	0.61
	rs3803	0.87 (0.57, 1.33)	0.52	0.76 (0.47, 1.22)	0.26
	rs2713604	1.27 (0.90, 1.81)	0.18	1.29 (0.88, 1.89)	0.20
NON-SMOKERS (n=268 [93 YA, 175 Controls])
CDGAP	rs10934490	1.41 (0.94, 2.13)	0.10	1.42 (0.91, 2.22)	0.13
MYLK	rs16834817	1.50 (0.84, 2.70)	0.17	1.75 (0.91, 3.37)	0.10
KALRN	rs6810298	1.00 (0.66, 1.53)	1.00	1.24 (0.76, 2.03)	0.39
	rs9289231	2.71 (1.45, 5.06)	0.002	3.05 (1.54, 6.05)	0.001
	rs12637456	1.26 (0.81, 1.96)	0.30	1.46 (0.89, 2.39)	0.13
	rs1444768	1.68 (1.09, 2.58)	0.018	1.54 (0.95, 2.50)	0.08
	rs1444754	1.36 (0.91, 2.03)	0.13	1.31 (0.84, 2.05)	0.23
	rs4234218	1.37 (0.91, 2.05)	0.13	1.33 (0.84, 2.10)	0.23
GATA2	rs2335052	1.21 (0.69, 2.12)	0.50	1.11 (0.60, 2.08)	0.74
	rs3803	0.80 (0.50, 1.29)	0.37	0.82 (0.48, 1.39)	0.46
	rs2713604	1.69 (1.08, 2.63)	0.021	2.10 (1.28, 3.46)	0.004

^*Basic model adjusted for sex only;

^†Full model adjusted for sex, BMI, diabetes, hypertension, hyperlipidemia, and smoking;

^‡All odds ratios are per additional variant allele under the additive genetic model.