Representative conformations extracted from basins B1, B2 and C of the free-energy surface. Top (as seen from the extracellular side) and side views of NLX bound (A, B) to the EL2/EL3 cleft on the DOR surface in the conformation extracted from the B1 basin, (C, D) to the EL2/EL3 cleft on the DOR surface in the conformation extracted from the B2 basin, and (E, F) within the helix bundle, in the conformation extracted from the C basin.