Table 1.
Molecular Weight and Area Under the Curve Ratios of Intraperitoneal Exposure to Systemic Exposure of Chemotherapeutic Agents Used to Treat Peritoneal Carcinomatosis
| Drug | Molecular Weight (Daltons) | Area Under the Curve Ratio |
|---|---|---|
| 5-Fluorouracil | 130.08 | 250 |
| Carboplatin | 371.25 | 10 |
| Cisplatin | 300.1 | 7.8 |
| Docetaxel | 861.9 | 552 |
| Doxorubicin | 579.99 | 230 |
| Etoposide | 588.58 | 65 |
| Floxuridine | 246.2 | 75 |
| Gemcitabine | 299.5 | 500 |
| Irinotecan | 677.19 | N/A |
| Melphalan | 305.2 | 93 |
| Mitomycin C | 334.3 | 23.5 |
| Mitoxantrone | 517.41 | 115-255 |
| Oxaliplatin | 397.3 | 16 |
| Paclitaxel | 853.9 | 1000 |
| Pemetrexed | 597.49 | 40.8 |