Table 1.

Diseases associated with AMPs.

Diseases	Peptides	Expression levels	Refs
Inflammatory skin diseases
Atopic dermatitis	LL37, defensins	Downregulatad	[93]
Psoriasis	LL37, defensins	Overexpressed	[93]
Rosacea	cathelicidins	Increased	[96]
Acne vulgaris	Defensins, granulysin	Induced	[78,110]
Lupus and contact dermatitis	LL37	Increased	[111]
Inflammatory bowel diseases
Ulcarative colitis	HD5.6; hBD2–4; lysozyme	upregulated	[112]
Crohn’s disease	α-defensins hBD2	Reduced in Paneth cells; low gene copy number of hBD2(≤3)	[94,113]
Gastrointestinal infections	LL37, hBD1	Downregulated	[113]
Respiratory diseases
Cystic fibrosis	LL37, β-defensins	Reduced antimicrobial activity because of salt accumulation	[114]