Table 4.

Cox Proportional Hazard Ratios (HRs) for Alzheimer Disease (AD) Incidence by Physical Activity and Mediterranean-Type Diet Score Dichotomous Ratings^a

Predictor	Unadjusted Model				Adjusted Model
	No. of Individuals		HR (95% CI)	P Value	No. of Individuals		HR (95% CI)b	P Value
	No Dementia	Incident AD			No Dementia	Incident AD
Physical activity + Mediterranean-type dietc
Low activity + low diet score	394	93	1 [Reference]		301	70	1 [Reference]
Low activity + high diet score	319	64	0.80 (0.58–1.10)	.17	250	49	0.77 (0.53–1.13)	.18
High activity + low diet score	452	68	0.67 (0.49–0.92)	.01	363	60	0.81 (0.57–1.16)	.26
High activity + high diet score	433	57	0.56 (0.40–0.78)	.001	338	45	0.65 (0.44–0.96)	.03
Trend (range, 1–4)	1598	282	0.85 (0.77–0.95)	.003	1252	224	0.87 (0.77–0.99)	.03
	Adjusted Model
			HR (95% CI)d				HR (95% CI)e
Low activity + low diet score	266	43	1 [Reference]		249	41	1 [Reference]
Low activity + high diet score	217	33	0.81 (0.51–1.29)	.38	202	32	0.70 (0.50–1.28)	.34
High activity + low diet score	332	38	0.68 (0.44–1.07)	.09	320	33	0.61 (0.38–0.97)	.04
High activity + high diet score	314	32	0.56 (0.35–0.89)	.02	307	29	0.51 (0.31–0.83)	.006
Trend (range, 1–4)	1129	146	0.85 (0.73–0.99)	.04	1078	135	0.83 (0.71–0.98)	.02

Abbreviation: CI, confidence interval.

^aAdjusted models include a slightly lower number of individuals because of missing data in some of the covariates.

^bAdjusted model simultaneously controls for cohort, age, sex, ethnicity, education, apolipoprotein E ε4 allele, caloric intake, body mass index (calculated as weight in kilograms divided by height in meters squared), smoking, depression, leisure activities, comorbidity index, baseline Clinical Dementia Rating score, and time between first dietary and first physical activity assessment.

^cLow physical activity was defined as a median of 0 hours per week; high physical activity was defined as a median of 1.3 hours per week of vigorous, 2.4 hours per week of moderate, or 3.8 hours per week of light physical activity, or a combination thereof. The cut point between low and high physical activity is 0.4 hours per week of vigorous, 0.7 hours per week of moderate, or 1.1 hours per week of light physical activity, or a combination thereof. The low Mediterranean-type diet score range is 0 to 4 and the high diet score range is 5 to 9.

^dAdjusted for everything in footnote “b” except Clinical Dementia Rating score. Individuals with a baseline Clinical Dementia Rating score of 0.5 were excluded from the analyses.

^eAdjusted for everything in footnote “b” except Clinical Dementia Rating score. Individuals with a baseline Clinical Dementia Rating score of 0.5 and less than 2 years of follow-up were excluded from the analyses.