. Author manuscript; available in PMC: 2010 May 27.

Published in final edited form as: J Med Chem. 2009 May 28;52(10):3397–3407. doi: 10.1021/jm900126v

Table 6.

Activity of ent-12b against Drug Resistant HCMV

Compound	Towne^b	EC₅₀ (µM)^a Virus Strain 2696r^c	E8^d
ent-12b	8	>100	72
cyclopropavir (3b)	0.6	28	8
ganciclovir (10)	2	42	22

Data from a plaque reduction assay with four drug concentrations in duplicate.

Wild-type virus from which isolates 2696r and E8 were obtained.

Virus isolated for resistance to cyclopropavir (3b) that has a truncated UL97 gene.

Virus with two point mutations introduced into gene UL97.