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. Author manuscript; available in PMC: 2009 Oct 21.
Published in final edited form as: J Am Chem Soc. 2008 Apr 25;130(20):6404–6410. doi: 10.1021/ja710254m

Scheme 2.

Scheme 2

General Synthesis of Focused Library 1,2,3-Triazole Substratesa

a Reagents: (a) CuI, i-Pr2EtN, THF, rt; (b) R’CO2H, triphosgene, THF, rt; (c) R’COH, NaBH(OAc)3, AcOH, THF, rt; (d) CF3CO2H, CH2Cl2, rt.